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ey0016.11-12 | Treatment of Severe Obesity: Next Steps | ESPEYB16

11.12. Patients with obesity caused by melanocortin-4 receptor mutations can be treated with a glucagon-like peptide-1 receptor agonist

EW Iepsen , J Zhang , HS Thomsen , EL Hansen , M Hollensted , S Madsbad , T Hansen , JJ Holst , JC Holm , SS Torekov

To read the full abstract: Cell Metabolism 2018; 28: 2332Pathogenic mutations in the melanocortin-4 receptor gene (MC4R) are the most common cause of monogenic obesity. However, very limited treatment options exist. Therefore, these authors investigated a glucagon-like peptide-1 receptor agonist (GLP-1 RA) as a treatment option for these patients. The findings are of major signific...

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ey0019.12-10 | Metabolic syndrome | ESPEYB19

12.10. Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis

P. Sato S, Dyar KA, Treebak JT, Jepsen SL, Ehrlich AM, Ashcroft SP, Trost K, Kunzke T, Prade VM, Small L, Basse AL, Schonke M, Chen S, Samad M, Baldi P, Barres R, Walch A, Moritz T, Holst JJ, Lutter D, Zierath JR, Sassone-Corsi

Cell metabolism 2022;34(2):329-45.e8. doi: 10.1016/j.cmet.2021.12.016Brief Summary: In a mouse model, time of exercise during the day was found to determine the magnitude and type of metabolic response. Different tissues responded to exercise at different times of the day.Comment: Exercise is considered a vital intervention in the prevention and treatment of individu...

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ESPE Yearbook of Paediatric Endocrinology

11.12. Patients with obesity caused by melanocortin-4 receptor mutations can be treated with a glucagon-like peptide-1 receptor agonist

12.10. Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis

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